
昆虫凝集素的免疫功能研究
Advances on the role of insect lectins in innate immunity
钟杰来** 韦婉婷 彭国俊 余小强 卢玉珍***
点击:14次 下载:2次
DOI:10.7679/j.issn.2095-1353.2025.127
作者单位:华南师范大学生命科学院,广东省昆虫发育调控与应用研究重点实验室,昆虫科学与技术研究所,广州 510631
中文关键词:C-型凝集素;半乳糖凝集素;先天免疫;模式识别蛋白;病原微生物
英文关键词: C-type lectins; galectins; innate immunity; pattern recognition receptors; pathogens
中文摘要:
昆虫主要依赖先天免疫来应对病原体的感染,而模式识别受体(Pattern recognition receptors,PRRs)对病原体的识别是激活免疫反应的基础。凝集素(Lectin)家族广泛存在于动物和植物中,通过糖识别结构域结合特定的糖类、糖蛋白或糖脂,在昆虫免疫中充当重要的模式识别受体。昆虫的凝集素主要包括C-型凝集素(C-type lectin)和半乳糖凝集素(Galectin),在先天免疫系统中承担着多种功能。本文概述了昆虫凝集素的分类、结构及其进化特征,重点总结了C-型凝集素和半乳糖凝集素在昆虫先天免疫系统中的功能,也简要介绍了凝集素在发育中的功能。本文为后续研究昆虫与微生物的免疫互作,以及靶向免疫系统改良微生物源农药提供参考。
英文摘要:
Insects primarily rely on innate immunity to defend against
pathogens, and the recognition of pathogens by pattern recognition receptors
(PRRs) to trigger immune responses. Lectins are widely present in animals and
plants, and they bind to specific carbohydrates, glycoproteins, or glycolipids
through their carbohydrate recognition domains (CRDs), thereby serving as
crucial PRRs in insect immunity. Insect lectins mainly include C-type lectins
and galectins which play multiple functions in the innate immune system. This
review outlines the classification, structure, and evolutionary characteristics
of insect lectins, with a focus on the functions of C-type lectins and
galectins in the insect innate immune system, and briefly introduces the
functions of insect lectins on growth. It is hoped that this review will
inspire studies of host-pathogen interactions, and contribute to the
improvement of microbial biopesticides targeting the immune system.